Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is used to treat type 2 diabetes and manage weight. While commercially available semaglutide products have specific expiration dates and storage instructions, understanding the shelf life of compound semaglutide—that is, semaglutide prepared in a compounding pharmacy—requires a more nuanced approach. There's no single, universally applicable answer.
The longevity of compounded semaglutide in the refrigerator heavily depends on several critical factors:
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The compounding pharmacy's practices: Reputable compounding pharmacies adhere to strict sterile procedures and quality control measures. Their adherence to these standards significantly impacts the stability and shelf life of the compounded medication. Look for accreditation from organizations like the Pharmacy Compounding Accreditation Board (PCAB).
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Storage conditions: Maintaining a consistent refrigerator temperature between 36°F and 46°F (2°C and 8°C) is crucial. Fluctuations in temperature can degrade the medication.
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The specific formulation: The other ingredients in the compounded semaglutide formulation can influence its stability. The presence of preservatives or other additives can either extend or shorten the shelf life.
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The packaging: The type of vial and the seal on the vial play a significant role in preventing contamination and degradation.
It's crucial to emphasize that there's no standardized expiration date for compounded semaglutide. Always follow the specific instructions provided by the compounding pharmacy. This information should be clearly stated on the label, which should include the preparation date and a recommended expiration date.
What Happens if Compounded Semaglutide is Not Properly Stored?
Improper storage can lead to:
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Reduced potency: The semaglutide may lose its effectiveness, meaning it won't work as well to manage your blood sugar or weight.
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Increased risk of contamination: Exposure to higher temperatures or improper handling can increase the risk of bacterial or fungal contamination, leading to infection if injected.
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Formation of degradation products: Semaglutide can break down into less effective or potentially harmful byproducts over time and with improper storage.
How Can I Ensure My Compounded Semaglutide Remains Stable?
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Obtain it from a reputable compounding pharmacy: Check for accreditation and inquire about their quality control procedures.
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Follow the storage instructions precisely: Keep it refrigerated at the correct temperature and protect it from light.
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Inspect the medication before each use: Look for any signs of discoloration, cloudiness, or particulate matter. If you notice anything unusual, do not use it and contact your pharmacy immediately.
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Discard it according to the provided instructions: Do not use the medication past the recommended expiration date.
How Long Does Commercially Available Semaglutide Last in the Fridge?
This is different from compounded medication. Commercially available semaglutide products, such as Ozempic or Wegovy, have clear expiration dates printed on the packaging. Always adhere to the manufacturer's instructions for storage and disposal. Generally, once opened, these products may have a slightly shorter usable timeframe than the expiration date printed on the box, so always check the manufacturer's guidelines.
What Are the Risks of Using Expired Compounded Semaglutide?
Using expired or improperly stored compounded semaglutide can pose several health risks, including:
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Ineffective treatment: The medication may not be potent enough to control your blood sugar or aid in weight loss.
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Adverse reactions: Degradation products could cause unexpected side effects.
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Infections: Contaminated medication can lead to serious infections at the injection site or systemic infections.
Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider or pharmacist before making any decisions about your medication, including storage and usage. They can provide personalized guidance based on your specific situation.
